Calcium and Calcium-binding proteins play a central role in signal transduction pathways and are associated with a wide range of effects on health and disease. My research is directed towards understanding the molecular basis for the cellular acitivities of Calmodulin (CaM) and more recently troponin C (TnC). Understanding the mechanism by with CaM and TnC are regulated is critical for many cellular processes including memory, growth and muscle contraction.
A.V. Gomes, J.A. Barnes & H. J. Vogel. Spectroscopic characterization of the interaction between calmodulin-dependent protein kinase I and calmodulin. Arch. Biochem. Biophys. 2000 in press.