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Aldrin V. Gomes, Ph.D.
University of California, Los Angeles
 
                                                 RECENT ABSTRACTS          

2006

Gomes, A.V., Drews, O., Li, X., Glen Young; Zong, C., Ping, P. (2006) Heterogeneity and Organ Specific Assembly of 20S Proteasomes. Mol. Cell. Proteomics in press.

Drews, O., Wildgruber, R., Zong, C., Sukop, U., Li ,X., Gomes, A.V., Nissum, M., Ping, P. (2006) Characterization of 20S proteasome subpopulations in mammalian tissues. Mol. Cell. Proteomics in press.

Mayr, M., Liem, D., Li, X., Avliyakulov, N., Yang, J-I., Young, G., Gomes, A.V., Vondriska, T.M., Madhu, B., Griffiths, J.R., Xu, Q., Ping P.(2006) Combined Proteomic and Metabolomic Analysis of PKC epsilon Transgenic mice. Mol. Cell. Proteomics in press.

Gomes, A.V., Liang, J., and Potter J. D. (2006) Characterization of Two Fast Skeletal Troponin I Mutations that cause Distal Arthrogryposis. Biophys. J. 90, B1634.

Gomes, A.V., Jones, M., Liang, J., Knee, S., Khan, A., and Potter J. D. (2006) Characterization of Known and Predicted Hypertrophic Cardiomyopathy Mutations at Arginine 204 of Human Cardiac Troponin I. Biophys. J. 90, B407.

Tikunova, S.B., Alionte, C., Gomes, A.V., Potter, J.D., and Davis, J.P. (2006) Effect of Cardiac Troponin C Mutations on Calcium Binding and Exchange with the Troponin Complex and Muscle Force Generation. Biophys. J. 90, B411.

Willott, R.H., Jones, M.A., Venkatraman, G., Gomes, A.V., and Potter, J.D. (2006) The presence of a Dilated Cardiomyopathy mutation in Cardiac Troponin T leads to reduced activation of the Thin filament in Functional Assays. Biophys. J. 90, B406.

2005

Gomes, A.V., Edmondson, R.D., Zong, C., Young, G.W., Liem, D.A., Wang, G.W. Jones, R.C., Thyparambil, S., Zhang, J., Pantaleon, D., Ping, D. (2005) Biochemical and Proteomic Characterization of the Murine Cardiac 26S proteasome. Mol. Cell. Proteomics 2005, 4.8, 15.13.

Zong, C., Gomes, A.V., Qiao, J., Berhane, B., Pantaleon, D., Loo, J., Ping, P. (2005) Phosphorylation is a Major Regulator of the Proteolytic Activity of Cardiac 26S Proteasomes. Mol. Cell. Proteomics 2005, 4.8, 15.14.

Gomes, A.V., Liang, J., and Potter, J.D. (2005) Mutations in Human Cardiac Troponin I that are associated with Restrictive Cardiomyopathy affect basal ATPase Activity and Calcium Sensitivity of Force Development. Biophys. J. 88, B535.

Gomes, A.V., Harada, K., Liang, J., Venkatraman, G., Guzman, G., and Potter, J.D. (2005) Determination of the Region of Troponin T that affects the pH dependent changes in the Calcium Sensitivity of Cardiac Muscle Contraction. Biophys. J. 88, B536.

Davis, J., Gomes, A.V., Tikunova, S.B., Rall, J.A., Potter, J.D. (2005) Effects of Familial Hypertrophic Cardiomyopathy (FHC) Mutations in Troponin I on Ca2+ Dissociation from the Troponin Complex and Ca2+-Sensitivity of Force Development. Biophys. J. 88, B453.

Venkatraman, G., Gomes, A.V., Kerrick, W.G.L., Potter, J. D. (2005) Investigation of Troponin T Mutations causing Dilated Cardiomyopathy utilizing Embryonic Troponin T and Troponin I Isoforms. Biophys. J. 88, B538.

Dweck, D., Gomes, A.V., Potter, J.D. (2005) Functional Effects of Human Cardiac Troponin C Mutations Linked to Familial and Dilated Cardiomyopathies. Biophys. J. 88, B537.

Compton, L.A., Miller, V.F., McFadden, L.A., Gomes, A.V., Potter, J.D., and Chase, P.B. (2005) Increased Calcium Sensitivity of Actin Filament Sliding by FHC Cardiac Troponin I Mutants D196N, and S199N. Biophys. J. 88, B529.

Gomes, A.V., Edmondson, R.D., Zong, C., Berhane, B., Young, G., Jones, R.C., Thyparambil, S., Pantaleon, D., Ping, D. (2005) Characterization of the Murine Cardiac 26S Proteasome by Biochemical and Proteomic Methods. Experimental Biology Meeting in San Diego, April 2-6th, 2005, FASEB J., A708.

Zong, C., Gomes, A.V., Berhane, B., Qiao, X., Edmondson, R., Pantaleon, D., Loo, J., Ping, P. (2005) Proteomic characterization of the murine 20S proteasome in normal and cardioprotected hearts. Experimental Biology Meeting in San Diego, April 2-6th, 2005, FASEB J., A389.

Gomes, A.V., Edmondson, R.D., Zong, C., Berhane, B., Ping, D. (2005) Proteomic Characterization of the Murine Cardiac 26S Proteasome. USHUPO 1st Annual Meeting, Washington, D.C., March 13-16th, 2005, L-204.

Zong, C., Gomes, A.V., Berhane, B., Pantaleon, D., Loo, J., Ping, P. (2005) Role of the Ubiqitin-Proteasome System in Cardioprotection. Keystone Symposium Meeting on Ubiquitin in Taos, New Mexico, February 22-27th, 2005, A350, pg74.

Gomes, A.V., Zong, C., Liem, D., Berhane, B., Ping, P. (2005) Role of the Ubiquitin-Proteasome System in Ischemia/Reperfusion Injury. Keystone Symposium Meeting on Ubiquitin in Taos, New Mexico, February 22-27th, 2005, A145, pg 49.

2004

Snyder, J.A., Hammett-Stabler, C.A., Potter, J.D., Gomes, A.V. (2004) A Troponin T mutation found in cardiomyopathy alters immunoassay response. Clinical Chem. 50:A9-A10.

Everhart, D., Cartier, G.E., Malhotra, A., Gomes, A.V., McIntosh, J.M., Luetje, C.W. (2004) The interaction between alpha-conotoxin-MII and the alpha3beta2 Neuronal Nicotinic Receptor. Society for Neuroscience, San Diego. Abstract No. 956.14.

Gomes, A.V., Venkatraman, G., Potter, J.D. (2004) Role of Cardiac Troponin T Isoforms in the function of fetal troponin. J. Muscle Research Cell Motility p17.

Gomes, A.V., Harada, K., Zhao, J., Ackerman, M.J., Potter, J.D. (2004) Physiological Effects of Cardiac Troponin I Mutations Classified as Polymorphisms. Biophys. J. 86:19A.

Gomes, A.V., Harada, K., Potter, J.D. (2004) Familial Hypertrophic Cardiomyopathy Mutation in the N-terminal of Troponin I affects the Ca2+-Sensitivity, Phosphorylation Kinetics and Proteolytic Susceptibility. Biophys. J. 86:216A.

Venkatraman, G., Gomes, A.V., Kerrick, G.W., Potter, J.D. (2004) Functional properties of Troponin T DCM mutants in the fetal Troponin T isoforms. Biophys. J. 86:395A.

2003

Gomes, A.V., Miller, T.E., Jaquez, O., Ampie, L., Potter, J.D. (2003) Impaired Regulatory Properties of a Truncated Slow Skeletal Troponin T that causes Nemaline Myopathy. Biophys. J. 84:1553, 319A.

Gomes, A.V., Zhao, J., Gendlina, E., Lopez, I., Potter, J.D. (2003) Physiological Effects of Cardiac Troponin I Mutations Associated with Adult Onset Familial Hypertrophic Cardiomyopathy. Biophys. J. 84:2780, 569A.

Venkatraman, G., Harada K., Gomes, A.V., Kerrick, G.W., Potter, J.D. (2003) Different functional properties of two troponin T mutants that cause Dilated Cardiomyopathy. Biophys. J. 84:1227, 253A.

Szczesna, D., Guzman, G., Gomes, A.V., Potter, J.D. (2003) Effect of the FHC Mutations in the Myosin Regulatory Light Chain on Its Interaction with a Myosin Heavy Chain Peptide. Biophys. J. 84:2193, 451A.

2002

Gomes A.V., Guzman G., Potter J.D. (2002) Alterations in muscle regulation by cardiac troponin T isoforms: Insights into the role of TnT in diseased hearts. Biophys. J. 82:1902

Gomes A.V., Miller T., Lang R., Housmans P.R., Zhao J., Lee K., Farkas B., Potter J.D. (2002) Functional analyses of troponin I mutations that cause Familial hypertrophic cardiomyopathy: Altered Ca2+ homeostasis. Biophys. J. 82:836

2001

Gomes A.V., Guzman G., and Potter J.D. (2001) Degradation of Fast skeletal Troponin T Isoforms by calpain. FASEB J. 15:A533

Gomes A.V., Guzman G., Jones M. and Potter J.D.(2001) Effect of different Isoforms of Troponin T on Actin-TM activated myosin ATPase activity. Biophys. J. 80:86A

Harada K.,Gomes A.V., and Potter J.D.( 2001) Variations in Secondary Structure caused by a single amino acid substitution in Human Cardiac Troponin T Mutants found in Familial Hypertrophic Cardiomyopathy. Biophys. J. 80:85A

deFreitas F., Jhao J., Miller T.E.,Gomes A.V., and Potter J.D. (2001) Rescue of a Transgenic Phenotype of Familial Hypertrophic Cardiomyopathy. Biophys. J. 80:85A

2000 Gomes, A.V., Barnes, J.A. and Potter, J.D. (2000) Role of the C-Terminal iNOS Calmodulin-Binding Region in Ca2+-Dependent Interactions with Calmodulin. 18th International Congress of Biochemistry and Molecular Biology, Birmingham, UK, July 16-20th, A933, pg 263.

Gomes, A.V., Jones, M., Barnes, J.A., Potter, J.D. (2000) Interaction of Troponin C Isoforms with Calmodulin-dependent Protein Kinase II CaM-binding Region. Biophys. J. 78:434A.

Gomes, A.V., Guzman, G., Urrea, E., Potter, J.D. (2000) Secondary Structure of Alternatively Spliced Fast Troponin T Isoforms. Biophys. J. 78:434A.

Cuervo, A.M., Dice, J,F., Gomes, A.V. and Barnes, J.A. (2000) Lyososmal targeting and degradation of annexins. 18th International Congress of Biochemistry and Molecular Biology, Birmingham, UK, July 16-20th, A1236, pg 337.

Lang, R., Satpaev, D., Gomes, A., Potter, J.D. (2000) Characterization of Human Cardiac Troponin I R145G: A Mutation Associated with Familial Hypertrophic Cardiomyopathy. Biophys. J. 78:435A.

Cuervo, A.M., Dice, J,F., Gomes, A.V. and Barnes, J.A. (2000) KFERQ Motifs target Annexins to Lysosomes. Sixth European Symposium on Calcium binding Proteins in normal and Transformed cells. Paris, June 14-17th, P26.

Potter, J.D., Miller, T., Culbreath, L., Zhao, J., McCue, J., de Freitas, F., Gomes, A., Zhang, R., Bell, M., Wang, Y., Xu, Y., Kerrick, G., Lang, R., Szczesna, D. (2000) Alterations of Cardiac Contractility in Transgenic Mice Over-expressing an FHC TnT Mutant (ILE79ASN). Biophys. J. 78:435A.

 

                                                                                         July 2006